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FSGS, Stage 3 Chronic Kidney Disease (CKD), 24h urine protein 18g, Creatinine 2.9, is it Curable

2012-10-02 14:40

Q:

FSGS was noticed from 2000 AD and named as FSGS. Now it is stage 3 chronic kidney disease, creatinine is up to 3 and 24h urine protein is up to 18gram. Is the disease curable?

A:

FSGS is a pathological diagnosis of kidney disorder. Focal refers to that only some of the glomeruli are involved (as opposed to diffuse), segmental means that only part of each glomerulus is damaged (as opposed to global). Glomerular cells are responsible for blocking proteins from running out of the body. In FSGS, the damaged glomerular cells will cause an excess loss of proteins, thus causing proteinuria. Massive proteinuria as what is mentioned is a dangerous sign, for heavy loss of proteins worsen fibrosis on renal tissues.

The creatinine 2.9 is a warning sign as well. Creatinine is a by-product of creatine that is produced in proportional to muscle activity. It is filtered out freely by the kidneys. Serum creatinine level is determined by Glomerular filtration rate(GFR), however, it is not as sensitive as GFR in detecting early damage of the kidneys. When serum creatinine increases, GFR has halved. Stage 3 Chronic Kidney Disease is diagnosed by GFR 30-60. This is a crucial stage.

If controlled timely and actively, progression of kidney damage can be slowed down. If poorly treated or controlled, the illness condition will get deteriorated just like a ball down the hill. As of now, the heavy proteins in urine, swelling and high blood pressure should be managed. In addition, if we want to stop further deterioration, treatment for eliminating renal fibrosis and repairing injured renal intrinsic cells is of great significance. By this, kidney function can get improved and the disease is managed well.

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