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What Are The Treatment Options For FSGS

2013-02-07 15:22

FSGS is the abbreviation of Focal Segmental Glomerulosclerosis and it is one of the most common chronic renal glomerular diseases. Proteinuria or nephrotic syndrome are the main manifestation of FSGS.

Patients can have stable illness conditions if they can achieve complete remission. However in some cases (about 30%-63%), patients’ illness conditions will continue to deteriorate and kidney functions will be gradually lost and they will in the end develop into renal failure.

Timely and proper treatments for FSGS including eliminating underlying causes and risk factors of FSGS, symptomatic diuretics, antihypertensive treatments as well as proper diets can much alleviate proteinuria and nephrotic syndrome, slow and prevent further illness progression.

The following are available treatment options for Focal Segmental Glomerulosclerosis.

1. Glucocorticoid---before patients develop hormonal resistance, prednisone is commonly prescribed drug for FSGS. Usually it takes about 3-4 months to achieve complete clinical remission. If nephrotic syndrome caused by FSGS can not be relieved after 6 months treatment, cyclophosphamide can be added to help increase remission rate, but the total dosage of cyclophosphamide should be less than 12g.

2. Ciclosporin---6 months ciclosporin treatment can reduce proteinuria, but reduction of dosage or stopping taking the medicine often cause relapse, therefore it needs to be taken as long term maintenance treatment.

3. Cytotoxic drugs---cytotoxic treatment can help lower recurrent rate.

4. Plasma exchange and protein adsorption---they can be used to treat recurrent FSGS after kidney transplant. Plasma exchange or protein adsorption can reduce circulating immune factors and temporarily reduce protein leakage in urine.

5. NSAIDs(Non-steroidal anti-inflammatory drugs) and ACEI---they can treat proteinuria and hyperlipoproteinemia. Others like azathioprine, MMF, ARB drugs can be selectively used according to the patient’s specific illness and physical conditions.

6. Chinese medicines---Chinese medicines can be combined with hormone and cytotoxic treatment to greatly enhance the curative effects. Chinese medicines can reduce side effects and complications of hormones and cytotoxic drugs and improve certain kidney functions so as to improve prognosis of FSGS and prolong patients’ life expectancy.

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Swelling is an obvious sign of Nephrotic Syndrome

Move the mouse to enlarge the picture Swelling is an obvious sign of Nephrotic Syndrome

Look, this patient has severe leg swelling which has made her feel pain and can not get out of the bed. In order to seek better treatment, she came to our hospital for Chinese medicine treatments. 30kg of fluid was removed from her body in less than a month. Her leg swelling disappeared completely. Now you can see her long legs again.

Proteinuria can also be seen in kidney patients

Move the mouse to enlarge the picture Proteinuria can also be seen in kidney patients

Look, this patient has severe proteinuria when he just came to our hospital. With our Chinese medicine treatments, his condition was better and better. Bubbles in urine gradually reduced and finally disappeared in 10 days of treatment.

New Zealand Patient Second Visit to Our Hospital for TCM

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